Laboratório Prof. Bruno Souza - Núcleo de Neurociências

Scientific Publications

2026

Resende, BL; Guimarães, JSF; Caetano, ALA; De Oliveira, ALM; Souza, BR; Oliveira, AG. Nationwide decline in psychiatric hospitalizations and costs in Brazil, 2008–2022: a retrospective descriptive study evidencing reform-driven community mental health gains . The Lancet Regional Health – Americas, Volume 56, 101425, 2026

2025

Moraes, MA; Arabe, LB; Resende, BL; Codo, BC; Reis, ALAL; Souza, BR . The gold standard control groups in physiological and pharmacological research are not that shiny: Intraperitoneal saline injection and needle pricking affect prepubescent mice's behavior in a sex-specific manner . Hormones and Behavior, vol. 169, p. 105707, 2025

2024

Souza, BR ; Codo, BC; Romano-Silva, MA; Tropepe, V. Darpp-32 is regulated by dopamine and is required for the formation of GABAergic neurons in the developing telencephalon . Progress in Neuro-Psychopharmacology & Biological Psychiatry, v. 134, p. 111060, 2024.

Moraes, MA; Arabe, LB; Resende, BL; Codo, BC; Reis, ALAL; Souza, BR . Effects of L-Dopa, SKF-38393, and Quinpirole on exploratory, anxiety- and depressive-like/despair behaviors in pubertal female and male mice . Behavioral Brain Research, vol. na, p. na, 2024

Rodrigues-Ribeiro, L.; Resende, BL; Pinto Dias, ML; Lopes, MR; de Barros, LLM; Moraes, MA; Verano-Braga, T.; Souza, BR . Neuroproteomics: Unveiling the Molecular Insights of Psychiatric Disorders with a Focus on Anxiety Disorder and Depression. Advances in Experimental Medicine and Biology. 1st ed.: Springer International Publishing, 2024, v., p. 103-128.

2022

Lemos, L.; Assis, HC; Alves, JL; Reis, DS; Campos Canesso, MC; Almeida Oliveira, M.; Moreira, TG; Miranda Sato, BK; Batista, LA; Gomes Lenzi, J.; Moraes, MA; Melo, L.; Resende, B.; Aguiar, D.; Rezende Souza, B .; Cara, DC; Gomes-Santos, AC; Faria, AMC. Neuroimmune circuits involved in β-lactoglobulin-induced food allergy. Brain Behavior & Immunity-Health, v. 23, p. 100471, 2022

2020

Matos, LO, Reis, ALAL, Guerra, LTL, Guarnieri, LO; Moraes, MA; Arab, LA; Souza, RP; Pereira, GS; Souza, BR. Early postnatal l-Dopa treatment causes behavioral alterations in female vs. male young adult Swiss mice. Neuropharmacology, 2020.

Lima, ACM; de Alvarenga, KAF;Codo, BC; Sacramento, E.K.; Pink, DVF; Souza, RP; Romano‐Silva, MA; Souza, BR. Impairment of motor but not anxiety-like behavior caused by the increase of dopamine during development is sustained in zebrafish larvae at later stages . International Journal of Developmental Neuroscience, 2020.

2018

Matos, LO; Reis, ALAL; Guerra, LTL; Guarnieri, LO; Moraes, MA; Aquino, NSS; Szawka, RE; Pereira, GS; Souza, B. R. L-Dopa treatment during perinatal development leads to different behavioral alterations in female vs. male juvenile Swiss mice . Pharmacology Biochemistry and Behavior, 2018.

2017

Rosa DVF, Magno LA, Souza BR , Romano-Silva MA. DARPP-32 . In: Encyclopedia of Signaling Molecules. 2nd ed.: New York, NY, 2017.

2016

de Alvarenga KAF, Sacramento EK, Rosa, DV, Souza BR , de Rezende VB, Romano-Silva MA. Effects of antipsychotics on intestinal motility in zebrafish larvae . Neurogastroenterology & Motility, 2016.

2015

Souza RP, Souza BR . Lewy Body Dementia and Frontotemporal Dementia . In: Young Perspectives for Old Diseases. 1st ed.: Bentham Books, 2015, v. , p. 251-267.

2014

Barros AGA, Bridi JC, Souza BR , De Castro Jr C, De Lima TorresKC, Malard L, Jorio A, Miranda DM, Ashrafi K, Romano-Silva MA. Dopamine Signaling Regulates Fat Content through β-Oxidation in Caenorhabditis elegans . Plos One, vol. 9, p. e85874, 2014.

2013

Rosa DVF, Magno LA, Souza BR , Romano-Silva MA. DARPP-32 . In: Encyclopedia of Signaling Molecules. 1st ed.: New York, NY, 2013, v. 1, p. 509-

2012

Brito-Melo GEA, Nicolato R, de Oliveira ACP, Menezes GB, Lélis FJN, Avelar RS, Sá J, Bauer ME, Souza BR , Teixeira AL, Reis HJ. Increase in dopaminergic, but not serotonergic, receptors in T-cells as a marker for schizophrenia severity . Journal of Psychiatric Research, v. 46, p. 738-742, 2012.

Miranda DM, Mamede M, Souza BR , Barros AGA, Magno LAV, Alvim-Soares Jr A, Rosa DVF, Castro CJ, Malloy-Diniz L, Gomez MV, De Marco LA, Correa H, Romano-Silva MA. Molecular medicine: a path towards a personalized medicine . Revista Brasileira de Psiquiatria, v. 31, p. 82-91, 2012.

2011

Souza BR , Romano-Silva MA, Tropepe V. Dopamine D2 Receptor Activity Modulates Akt Signaling and Alters GABAergic Neuron Development and Motor Behavior in Zebrafish Larvae . The Journal of Neuroscience, vol. 31, p. 5512-5525, 2011.

Souza BR , Torres KCL, Miranda DM, Motta BS, Caetano FS, Rosa DVF, Souza RP, Giovani Júnior A, Carneiro DS, Guimarães MM, Martins-Silva C, Reis HJ, Gomez MV, Jeromin A, Romano-Silva MA. Downregulation of the cAMP/PKA Pathway in PC12 Cells Overexpressing NCS-1 . Cellular and Molecular Neurobiology, v. 31, p. 135-143, 2011.

Souza BR , Tropepe V. The role of dopaminergic signaling during larval zebrafish brain development: a tool for investigating the developmental basis of neuropsychiatric disorders . Reviews in the Neurosciences, vol. 22, p. 107-119, 2011.

Pereira PA, Romano-Silva MA, Bicalho MAC, De Marco LA, Correa H, Campos SB, Moraes EN, Torres KCL, de Souza BR , Miranda DM. Association Between Tryptophan Hydroxylase-2 Gene and Late-Onset Depression . The American Journal of Geriatric Psychiatry, v. 19, p. 1, 2011.

Torres KCL, Pereira PA, Lima GS, Souza BR , Miranda DM, Bauer ME, Romano-Silva MA. Immunosenescence . Brazilian Journal of Geriatrics and Gerontology, v. 5, p. 163-169, 2011

2010

Souza BR , Torres KCL, Miranda DM, Motta BS, Scotti-Muzzi E, Guimarães MM, Carneiro DS, Rosa DVF, Souza RP, Reis HJ, Jeromin A, Romano-Silva MA. Lack of effects of typical and atypical antipsychotics on DARPP-32 and NCS-1 levels in PC12 cells overexpressing NCS-1 . Journal of Negative Results In Biomedicine, v. 9, p. 4, 2010.

Rosa DVF, Souza RP, Souza BR , Lima FF, Valvassori S, Gomez MV, Quevedo J, Romano-Silva MA. Inhibitory avoidance task does not change NCS-1 level in rat brain . Brain Research Bulletin, vol. 82, p. 289-292, 2010.

Campos SB, Miranda DM, Souza BR , Pereira PA, Neves FS, Bicalho MAC, Melillo PHC, Tramontina J, Kapczinski F, Romano-Silva MA, Correa H. Association of polymorphisms of the tryptophan hydroxylase 2 gene with risk for bipolar disorder or suicidal behavior . Journal of Psychiatric Research, vol. 44, p. 271-274, 2010.

Campos SB, Miranda DM, Souza BR , Pereira PA, Neves FS, Tramontina J, Kapczinski F, Romano-Silva MA, Correa H. Association study of tryptophan hydroxylase 2 gene polymorphisms in bipolar disorder patients with panic disorder comorbidity . Psychiatric Genetics, Apr;21(2):106-11, 2010.

Cordeiro Q, Vallada H, Souza BR , Correa H, Romano-Silva MA, Guindalini C, Hutz MH. Population stratification in European South-American subjects and its importance to psychiatric genetics research in Brazil . Revista Brasileira de Otorrinolaringologia, v. 32, p. 92-94, 2010.

2009

Torres KCL, Souza BR , Miranda DM, Nicolato R, Neves FS, Barros AGA, Dutra WO, Gollob KJ, Correa H, Romano-Silva MA. The leukocytes expressing DARPP-32 are reduced in patients with schizophrenia and bipolar disorder . Progress in Neuro-Psychopharmacology & Biological Psychiatry, v. 33, p. 214-219, 2009.

Torres KCL, Souza BR , Miranda DM, Sampaio Am, Nicolato R, Neves FS, Barros AGA, Dutra WO, Gollob KJ, Correa H, Romano-Silva MA. Expression of neuronal calcium sensor-1 (NCS-1) is decreased in leukocytes of schizophrenia and bipolar disorder patients . Progress in Neuro-Psychopharmacology & Biological Psychiatry, v. 33, p. 229-234, 2009.

Cordeiro Q, Souza BR , Correa H, Guindalini C, Hutz MH, Vallada H, Romano-Silva MA. A review of psychiatric genetics research in the Brazilian population . Brazilian Journal of Psychiatry, v. 31, p. 154-162, 2009.

Souza RP, Soares EC, Rosa DVF, Souza BR , Gomes KM, Valvassori SS, Reus GZ, Inacio CG, Martins MR, Gomez MV, Quevedo J, Romano-Silva, MA. Cerebral DARPP-32 expression after methylphenidate administration in young and adult rats . International Journal of Developmental Neuroscience, vol. 27, p. 1-7, 2009.

2008