Laboratório Prof. Bruno Souza - Núcleo de Neurociências

Publicações Científicas

2026

Resende, BL; Guimarães, JSF; Caetano, ALA; De Oliveira, ALM; Souza, BR; Oliveira, AG. Nationwide decline in psychiatric hospitalizations and costs in Brazil, 2008–2022: a retrospective descriptive study evidencing reform-driven community mental health gains. The Lancet Regional Health – Americas, Volume 56, 101425, 2026

2025

Moraes, M.A.; Arabe, L.B; Resende, B.L; Codo, B.C.; Reis, A.L.A.L.; Souza, B.R. The gold standard control groups in physiological and pharmacological research are not that shiny: Intraperitoneal saline injection and needle pricking affect prepubescent mice's behavior in a sex-specific manner. Hormones and Behavior, v. 169, p. 105707, 2025

2024

Souza, B.R; Codo, B.C.; Romano-Silva, M.A.; Tropepe, V. Darpp-32 is regulated by dopamine and is required for the formation of GABAergic neurons in the developing telencephalon. Progress in Neuro-Psychopharmacology & Biological Psychiatry, v. 134, p. 111060, 2024.

Moraes, M.A.; Arabe, L.B.; Resende, B.L.; Codo, B.C.; Reis, A.L.A.L.; Souza, B.R. Effects of L-Dopa, SKF-38393, and Quinpirole on exploratory, anxiety- and depressive-like/despair behaviors in pubertal female and male mice. Behavioral Brain Research, v. na, p. na, 2024

Rodrigues-Ribeiro, L.; Resende, B.L.; Pinto Dias, M.L.; Lopes, M.R; de Barros, L.L.M; Moraes, M.A.; Verano-Braga, T.; Souza, B.R. Neuroproteomics: Unveiling the Molecular Insights of Psychiatric Disorders with a Focus on Anxiety Disorder and Depression. Advances in Experimental Medicine and Biology. 1ed.: Springer International Publishing, 2024, v. , p. 103-128.

2022

Lemos, L.; Assis, H.C.; Alves, J.L.; Reis, D.S.; Campos Canesso, M.C.; Almeida Oliveira, M.; Moreira, T.G.; Miranda Sato, B.K.; Batista, L.A.; Gomes Lenzi, J.; Moraes, M.A. ; Melo, L.; Resende, B.; Aguiar, D.; Rezende Souza, B.; Cara, D.C.; Gomes-Santos, A.C; Faria, A.M.C. Neuroimmune circuits involved in β-lactoglobulin-induced food allergy. Brain Behavior & Immunity-Health, v. 23, p. 100471, 2022

2020

Matos, L.O., Reis, A.L.A.L., Guerra, L.T.L., Guarnieri, L.O.; Moraes, M.A.; Arabe, L.A.; Souza, R.P.; Pereira, G.S.; Souza, B.R.. Early postnatal l-Dopa treatment causes behavioral alterations in female vs. male young adult Swiss mice. Neuropharmacology, 2020.

Lima, A.C.M.; de Alvarenga, K.A.F.;Codo, B.C.; Sacramento, E.K.; Rosa, D.V.F.; Souza, R.P.; Romano‐Silva, M.A.; Souza, B.R.. Impairment of motor but not anxiety‐like behavior caused by the increase of dopamine during development is sustained in zebrafish larvae at later stages. International Journal of Developmental Neuroscience, 2020.

2018

Matos, L. O. ; Reis, A. L. A. L. ; Guerra, L. T. L. ; Guarnieri, L. O. ; Moraes, M. A. ; Aquino, N. S. S. ; Szawka, R. E. ; Pereira, G. S. ; Souza, B. R. . l -Dopa treatment during perinatal development leads to different behavioral alterations in female vs. male juvenile Swiss mice. Pharmacology Biochemistry and Behavior, 2018.

2017

Rosa DVF, Magno LA, Souza BR, Romano-Silva MA. DARPP-32. In: Encyclopedia of Signaling Molecules. 2ed.: New York, NY, 2017.

2016

de Alvarenga KAF, Sacramento EK, Rosa, DV, Souza BR, de Rezende VB, Romano-Silva MA. Effects of antipsychotics on intestinal motility in zebrafish larvae. Neurogastroenterology & Motility, 2016.

2015

Souza RP, Souza BR. Lewy Body Dementia and Frontotemporal Dementia. In: Young Perspectives for Old Diseases. 1ed.: Bentham Books, 2015, v. , p. 251-267.

2014

Barros AGA, Bridi JC, Souza BR, De Castro Jr C, De Lima TorresKC, Malard L, Jorio A, Miranda DM, Ashrafi K, Romano-Silva MA. Dopamine Signaling Regulates Fat Content through β-Oxidation in Caenorhabditis elegans. Plos One, v. 9, p. e85874, 2014.

2013

Rosa DVF, Magno LA, Souza BR, Romano-Silva MA. DARPP-32. In: Encyclopedia of Signaling Molecules. 1ed.: New York, NY, 2013, v. 1, p. 509-

2012

Brito-Melo GEA, Nicolato R, de Oliveira ACP, Menezes GB, Lélis FJN, Avelar RS, Sá J, Bauer ME, Souza BR, Teixeira AL, Reis HJ. Increase in dopaminergic, but not serotoninergic, receptors in T-cells as a marker for schizophrenia severity. Journal of Psychiatric Research, v. 46, p. 738-742, 2012.

Miranda DM, Mamede M, Souza BR, Barros AGA, Magno LAV, Alvim-Soares Jr A, Rosa DVF, Castro CJ, Malloy-Diniz L, Gomez MV, De Marco LA, Correa H, Romano-Silva MA. Molecular medicine: a path towards a personalized medicine. Revista Brasileira de Psiquiatria, v. 31, p. 82-91, 2012.

2011

Souza BR, Romano-Silva MA, Tropepe V. Dopamine D2 Receptor Activity Modulates Akt Signaling and Alters GABAergic Neuron Development and Motor Behavior in Zebrafish Larvae. The Journal of Neuroscience, v. 31, p. 5512-5525, 2011.

Souza BR, Torres KCL, Miranda DM, Motta BS, Caetano FS, Rosa DVF, Souza RP, Giovani Júnior A, Carneiro DS, Guimarães MM, Martins-Silva C, Reis HJ, Gomez MV, Jeromin A, Romano-Silva MA. Downregulation of the cAMP/PKA Pathway in PC12 Cells Overexpressing NCS-1. Cellular and Molecular Neurobiology, v. 31, p. 135-143, 2011.

Souza BR, Tropepe V. The role of dopaminergic signalling during larval zebrafish brain development: a tool for investigating the developmental basis of neuropsychiatric disorders. Reviews in the Neurosciences, v. 22, p. 107-119, 2011.

Pereira PA, Romano-Silva MA, Bicalho MAC, De Marco LA, Correa H, Campos SB, Moraes EN, Torres KCL, de Souza BR, Miranda DM. Association Between Tryptophan Hydroxylase-2 Gene and Late-Onset Depression. The American Journal of Geriatric Psychiatry, v. 19, p. 1, 2011.

Torres KCL, Pereira PA, Lima GS, Souza BR, Miranda DM, Bauer ME, Romano-Silva MA. Imunossenescência. Revista Brasileira de Geriatria e Gerontologia, v. 5, p. 163-169, 2011

2010

Souza BR, Torres KCL, Miranda DM, Motta BS, Scotti-Muzzi E, Guimarães MM, Carneiro DS, Rosa DVF, Souza RP, Reis HJ, Jeromin A, Romano-Silva MA. Lack of effects of typical and atypical antipsychotics in DARPP-32 and NCS-1 levels in PC12 cells overexpressing NCS-1. Journal of Negative Results In Biomedicine, v. 9, p. 4, 2010.

Rosa DVF, Souza RP, Souza BR, Lima FF, Valvassori S, Gomez MV, Quevedo J, Romano-Silva MA. Inhibitory avoidance task does not change NCS-1 level in rat brain. Brain Research Bulletin, v. 82, p. 289-292, 2010.

Campos SB, Miranda DM, Souza BR, Pereira PA, Neves FS, Bicalho MAC, Melillo PHC, Tramontina J, Kapczinski F, Romano-Silva MA, Correa H. Association of polymorphisms of the tryptophan hydroxylase 2 gene with risk for bipolar disorder or suicidal behavior. Journal of Psychiatric Research, v. 44, p. 271-274, 2010.

Campos SB, Miranda DM, Souza BR, Pereira PA, Neves FS, Tramontina J, Kapczinski F, Romano-Silva MA, Correa H. Association study of tryptophan hydroxylase 2 gene polymorphisms in bipolar disorder patients with panic disorder comorbidity. Psychiatric Genetics, Apr;21(2):106-11, 2010.

Cordeiro Q, Vallada H, Souza BR, Correa H, Romano-Silva MA, Guindalini C, Hutz MH. Population stratification in European South-American subjects and its importance to psychiatric genetics research in Brazil. Revista Brasileira de Otorrinolaringologia, v. 32, p. 92-94, 2010.

2009

Torres KCL, Souza BR, Miranda DM, Nicolato R, Neves FS, Barros AGA, Dutra WO, Gollob KJ, Correa H, Romano-Silva MA. The leukocytes expressing DARPP-32 are reduced in patients with schizophrenia and bipolar disorder. Progress in Neuro-Psychopharmacology & Biological Psychiatry, v. 33, p. 214-219, 2009.

Torres KCL, Souza BR, Miranda DM, Sampaio Am, Nicolato R, Neves FS, Barros AGA, Dutra WO, Gollob KJ, Correa H, Romano-Silva MA. Expression of neuronal calcium sensor-1 (NCS-1) is decreased in leukocytes of schizophrenia and bipolar disorder patients. Progress in Neuro-Psychopharmacology & Biological Psychiatry, v. 33, p. 229-234, 2009.

Cordeiro Q, Souza BR, Correa H, Guindalini C, Hutz MH, Vallada H, Romano-Silva MA. A review of psychiatric genetics research in the Brazilian population. Revista Brasileira de Psiquiatria, v. 31, p. 154-162, 2009.

Souza RP, Soares EC, Rosa DVF, Souza BR, Gomes KM, Valvassori SS, Reus GZ, Inacio CG, Martins MR, Gomez MV, Quevedo J, Romano-Silva, MA. Cerebral DARPP-32 expression after methylphenidate administration in young and adult rats. International Journal of Developmental Neuroscience, v. 27, p. 1-7, 2009.

2008